Cargo docente: JTP
Área: Biología Molecular y Celular
Materias de grado: Introducción a la Biología Molecular y Celular / Fundamentos de Biología Molecular y Fisiología Celular
Materias de posgrado:
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Dr. Mariano Soiza Reilly
Cargo CONICET: Inv. Independiente
Tema de Investigación: Neurobiología de Circuitos y Trastornos Psiquiátricos
Descripción del tema: Las enfermedades psiquiátricas como la depresión, la ansiedad y la vulnerabilidad al estrés representan unas de las condiciones mentales más incapacitantes para la vida de los seres humanos. Recientes estudios sugieren que muchos aspectos de dichas patologías podrían tener un origen temprano durante la infancia de los individuos. Nuestro grupo está interesado en entender los mecanismos por los cuales modificaciones en la formación y maduración de circuitos cerebrales durante distintas etapas del neurodesarrollo pueden contribuir a la etiología temprana de enfermedades psiquiátricas.
Campos RC, Marti F, Rigoni D, Fofo H, Pousinha P, Ortiz V, Royon L, Violain M, Heck N, Faure P, Soiza-Reilly, M., Fernandez SP, Barik J. 2026. Nicotine disrupts top down habenular control over cholinergic inputs to the ventral tegmental area to increase motivational valence of food rewards. Biol Psychiatry 99(6):492-505. doi: 10.1016/j.biopsych.2025.06.
Contesse, T., Gomes-Ribeiro, J., Royon, L., Fofo, H., Braine, A., Glangetas, C., Zhang, S., Barbano, M. F., Soiza-Reilly, M., Georges, F., Barik, J., Fernandez, S.P. 2025. Social stress increases anxiety by GluA1-dependent synaptic strengthening of ventral tegmental area inputs to the basolateral amygdala. Biol Psychiatry 98(10):788-801. doi: 10.1016/j.biopsych.2025.04.
Facal CL, Bessone IF, Muñiz JA, Pereyra AE, Pedroncini O, Páez-Paz I, Clerici-Delville R, Arnaiz C, Urrutia L, Falasco G, Argañaraz CV, Saez T, Marin-Burgin A, Soiza-Reilly M, Falzone T, Avale ME. 2024. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice. Mol Ther. 32(4):1080-1095. doi: 10.1016/j.ymthe.2024.01.033.
Romero, D.M.; Poirier, K.; Belvindrah, R.; Moutkine, I.; Houllier, A.; Lemoing, A-G.; Petit, F.; Boland, A.; Collins, S.C.; Soiza-Reilly, M.; Yalcin, B.; Chelly, J.; Deleuze, J.F.; Bahi-Buisson, N.; Francis, F. 2022. Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development. Nat Commun 13:2746. doi:10.1038/s41467-022-30443-
*Adjimann, T.S., *Argañaraz, C.V., Soiza-Reilly, M. 2021. Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders. Transl Psychiatry 11(1):280. doi: 10.1038/s41398-021-01388-6.
*Arganaraz, C.V., *Adjimann, T.S., Perissinotti, P.P., Soiza-Reilly, M. 2022. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development 149(24):dev201121. doi: 10.1242/dev.201121.
Linders, L.E., Patrikiou, L., Soiza-Reilly, M., Schut, E.H.S., van Schaffelaar, B.F., Böger, L., Wolterink-Donselaar, I.G., Luijendijk, M.C.M., Adan, R.A.H., Meye, F.J. 2022. Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food. Nat Commun 13(1):6898. doi: 10.1038/s41467-022-34625-7.
Soiza-Reilly, M. 2022. Transcriptional preservation of serotonergic connectivity may shed light on neurodegeneration. Trends in Neurosciences 45(8):563-565. doi: 10.1016/j.tins.2022.05.004.
Damianich, A., Facal, C., Minnini, C., Soiza-Reilly, M., Ponce de Leon, M., Urrutia, L., Falasco, G., Ferrario, J., Avale, M. 2021. Tau mis-splicing correlates with motor impairments and striatal dysfunction in a model of tauopathy. Brain 144:2302-2309. doi: 10.1093/brain/awab130.
Muzerelle, A., Soiza-Reilly, M., Hainer, C., Ruet, P.L., Lesch, K.P., Bader, M., Alenina, N., Scotto-Lomassese, S., Gaspar, P. 2021. Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Sci Rep 11:6004. doi: 10.1038/s41598-021-84368-6.
Nuno-Perez, A., Trusel, M., Lalive, A.L., Congiu, M., Gastaldo, D., Tchenio, A., Lecca, S., Soiza-Reilly, M., Bagni, C., Mameli, M. 2021. Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula. Neuron 109:1-10. doi: 10.1016/j.neuron.2021.01.008.
Olusakin, J., Moutkine, I., Dumas, S., Ponimaskin, E., Paizanis, E., *Soiza-Reilly, M., *Gaspar, P. 2020. Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development. Neuropsychopharmacology 45(13):2267-2277. doi: 10.1038/s41386-020-0775-z.
Soiza-Reilly, M., Meye, F.J., Olusakin, J., Telley, L., Petit, E., Chen, X., Mameli, M., Jabaudon, D., Sze, J.Y., Gaspar, P. 2019. SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior. Mol Psychiatry 24(5):726-745. doi: 10.1038/s41380-018-0260-9.
*Teissier, A., *Soiza-Reilly, M., Gaspar, P. 2017. Refining the role of 5-HT in postnatal development of brain circuits. Front Cellular Neurosci 11:139.
Meye, F.J., Soiza-Reilly, M., Smit, T., Diana, M.A., Schwarz, M.K., Mameli, M. 2016. Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse. Nat Neurosci 19(8):1019-24.
Muzerelle A, Scotto-Lomassese S, Bernard JF, Soiza-Reilly M, Gaspar P. 2016. Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem. Brain Struct Funct 221:535-61.
Soiza-Reilly, M., Goodfellow, N.M., Lambe, E.K., Commons, K.G. 2015. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology 89: 185-192.
*Soiza-Reilly, M., Commons, K.G. 2011. Quantitative analysis of glutamatergic Innervation of the mouse dorsal raphe nucleus using array tomography. J Comp Neurol 519 (18): 3802-3814.