Dr. Matías Blaustein Klappelmacher

Cargo docente: JTP
Area: Biología Molecular y Celular
Materias de grado: Genética Molecular
Materias de posgrado: Biología Sintética
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Cargo Conicet: Investigador Adjunto
Área: Biología Molecular y Celular
Tema de Trabajo: Biología de Sistemas y Filosofía del Cáncer
Descripción de trabajo: Estudiamos los mecanismos moleculares que regulan la toma de decisión celular y que nos permiten predecir la resistencia a drogas antitumorales. Utilizamos reporteros fluorescentes para analizar las dinámicas de activación de proteínas de señalización en células individuales. Por otro lado, analizamos mediante modelos matemáticos el rol del cáncer a nivel evolutivo. Asimismo, nuestro grupo estudia cómo los contaminantes del agua y la tierra influyen en procesos tumorales y de estrés celular.

AKT
Blaustein M.
Encyclopedia of Signaling Molecules (2018). Springer, 2nd Edition. New York, NY, pp 267-280.

Yeast GPCR signaling reflects the fraction of occupied receptors, not the number
Bush, A.*; Vasen, G.*; Constantinou, A.**; Dunayevich, P.**; Patop, I.L.; Blaustein, M. and Colman-Lerner, A
* y ** contribuyeron equivalentemente
Molecular Systems Biology (2016), 12 (12): 898
Seleccionado en Faculty of 1000 Biology, 01 Feb 2017,
https://f1000.com/prime/727154419?bd=1&ui=28953

Akt/PKB: one kinase, many modifications.
Risso,G.; Blaustein, M.*; Pozzi, B*.; Mammi, P. and Srebrow, A.
* contribuyeron equivalentemente
Biochemical Journal (2015), 468(2):203-14

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells.
Allo, M; Agirre, E.; Bessonov, S.; Bertucci, P; Gómez Acuña, L; Buggiano, V; Bellora, N; Singh, B.; Petrillo, E; Blaustein, M; Miñana Gómez, B; Dujardin, G; Pozzi, B; Pelisch, F.; Bechara, E.; Srebrow, A.; Lührmann, R.; Valcárcel, J; Eyras, E. and Kornblihtt, A.
Proc Natl Acad Sci U S A. (2014), 111(44):15622-29

Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle.
Risso,G.; Pelisch, F.; Pozzi, B.; Mammi, P.; Blaustein, M.; Colman-Lerner, A and Srebrow, A.
Cell Cycle (2013), 12(19):3165-74

Modulation of the Akt pathway reveals a novel link with PERK/eIF2, which is relevant during hypoxia. Blaustein, M.*; Pérez-Munizaga, D.*, Urrutia, C.; Sánchez,M.A.; Grande,A.; Risso,G.; Srebrow, A.; Alfaro, J.** and Colman-Lerner, A.A.**
* y ** contribuyeron equivalentemente
PLoS ONE, (2013), 8(7): e69668. doi:10.1371/journal.pone.0069668

Involvement of hnRNP A1 in the matrix metalloprotease-3- dependent regulation of Rac1 pre-mRNA splicing.
Pelisch, F.; Khauv, D.; Risso, G.; Stallings-Mann, M.; Blaustein, M.; Quadrana, L.; Radisky, D.C.; and Srebrow, A.
Journal of Cellular Biochemistry, (2012), 113(7):2319-29

PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer.
Riggio, M.; Polo, M.L.; Blaustein, M.; Colman-Lerner, A.; Lüthy, I.; Lanari, C.; and Novaro, V.
Carcinogenesis (2012), 33(3):509-18

Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells.
Schere Levy, C.; Slomiansky, V.; Gattelli, A.; Nahmod, K.; Pelisch, F.; Blaustein, M.; Srebrow, A.; Coso, O.A. and Kordon E.C.
Journal of Cellular Biochemistry (2010), 110(4):857-865.

SF2/ASF regulates proteomic diversity by affecting the balance between translation initiation mechanisms.
Blaustein, M.; Quadrana, L.; Risso, G.; de la Mata, M; Pelisch, F. and Srebrow, A.
Journal of Cellular Biochemistry (2009), 107(4):826-33.

DNA damage regulates alternative splicing through changes in Pol II elongation.
Muñoz, M.J.; Pérez Santangelo, M.S.; Paronetto, M.P.; de la Mata, M.; Pelisch, F.; Boireau, S.; Glover-Cutter, K.; Ben-Dov, C.; Blaustein, M; Lozano, J.J.; Bird, G.; Bentley, D.; Bertrand, E. and Kornblihtt, A.R.
Cell (2009), 137: 708-720

Signals, pathways and splicing regulation.
Blaustein, M.*; Pelisch, F.* and Srebrow, A.
* contribuyeron equivalentemente
International Journal of Biochemistry & Cell Biology (2007) 39: 2031-2048.

Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT.
Blaustein, M.; Pelisch, F.; Tanos, T.; Muñoz, M.J.; Wengier, D.; Quadrana, L.; Sanford, J.R.; Muschietti, J.P.; Kornblihtt, A.R.; Cáceres, J.F.; Coso, O.A. and Srebrow, A.
Nature Structural and Molecular Biology (2005), 12:1037-1044.
Seleccionado artículo del mes en Nature Structural and Molecular Biology
Comentado en “News and Views”, Nature Structural and Molecular Biology (2005) 12 (12): 1022-1023.
Seleccionado en Faculty of 1000 Biology, 19 Dic 2005,
https://f1000.com/prime/1029727

Cross-talk between signaling pathways regulates alternative splicing: A novel role for JNK.
Pelisch, F.; Blaustein, M.; Kornblihtt, A.R. and Srebrow, A.
Journal of Biological Chemistry (2005), 280: 25461-69.
Comentado en Science STKE, Vol. 2005, Issue 292, pp. 251, 12 de Julio 2005.

Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase.
Blaustein, M.; Pelisch, F.; Coso, O.A.; Bissell, M.J.; Kornblihtt A.R. and Srebrow, A.
Journal of Biological Chemistry (2004), 279:21029-37.

A slow RNA polymerase II affects alternative splicing in vivo.
de la Mata, M.; Alonso, C.R.; Kadener, S.; Fededa, J.P.; Blaustein, M.; Pelisch, F.; Cramer, P.; Bentley, D.; and Kornblihtt, A.R.
Molecular Cell (2003), 12: 525-532.
Revista extranjera con referato.
Seleccionado en Faculty of 1000 Biology, 23 Sep 2003,
https://f1000.com/prime/1015585

Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better.
Nogués, G.; Kadener, S.; Cramer, P.; de la Mata, M.; Fededa, J.P.; Blaustein, M.; Srebrow, A. and Kornblihtt, A.R.
IUBMB Life (2003), 55: 235-241.

Regulation of fibronectin alternative splicing by a basement membrane-like extracellular matrix.
Srebrow, A.; Blaustein, M. and Kornblihtt, A.R.
FEBS Letters (2002), 514: 285-289.