Cargo Conicet: Investigador Superior
Área: Fisiología y Neurociencias
Tema de Trabajo: Rol de los protones y los canales activados por el en la transmision sinaptica y en la plasticidad
Descripción de trabajo: Mediante técnicas electrofisiológicas, inmunohistoquímicas, bioquímicas y de biología molecular estudiamos la participación de los canales ASIC (acid sensing ion channels) en la fisiología y plasticidad sináptica. En particular estudiamos la expresión y regulación de los canales ASIC en el dolor y sus implicancias para la enfermedad de Fabry caracterizada por la acumulación de glucoesfingolípidos en los tejidos incluyendo los nervios periféricos y las neuronas de la vía del dolor.

PUBLICACIONES del 2010 al 2019)

1. Uchitel OD, Inchauspe CG, Weissmann C. Synaptic signals mediated by protons and acid sensing ion channels. Synapse. 2019 Jun 10. doi: 10.1002/syn.22120. [Epub ahead of print]
2. Gatto RG, Amin M, Finkielsztein A, Weissmann C, Barrett T, Lamoutte C, Uchitel O, Sumagin R, Mareci TH, Magin RL. Unveiling early cortical and subcortical neuronal degeneration in ALS mice by ultra-high field diffusion MRI. Amyotroph.Lateral Scler Frontotemporal Degener. 2019 Jun 3:1-13. doi: 10.1080/21678421.2019.1620285.
3. González-Inchauspe C, Gobetto MN, Uchitel OD. Modulation of acid sensing ion channel dependent protonergic neurotransmission at the mouse calyx of Held. Neuroscience. 2019 Apr 22. pii: S0306-4522(19)30263-5. doi: 10.1016/j.neuroscience.2019.04.023. [Epub ahead of print]
4. González-Inchauspe C, Urbano FJ, Di Guilmi MN, Uchitel OD. Acid-Sensing IonChannels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse. J Neurosci. 2017, 37(10):2589-2599.
5. .Bertone NI, Groisman AI, Mazzone GL, Cano R, Tabares L, Uchitel OD. Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction. Synapse. 2017. 71(12).
6. Mazzone GL, Veeraraghavan P, Gonzalez-Inchauspe C, Nistri A, Uchitel OD. ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury. Neuroscience. 2017, 343:398-410.
7. Lezio S. Bueno-J. , Ruggiero RN, Rossignoli MT, Del Bel E,Leite J:P. and Uchitel OD. Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo. Physiological Reports , 2017 Jan;5(1). pii: e13066
8. Lempel AA, Coll L, Schinder AF, Uchitel O, Piriz J. Chronic Pregabalin Treatment Decreases Excitability of Dentate Gyrus and Accelerates Maturation of Adult-born Granule Cells. J Neurochem. 2016 140(2):257-267.
9. Pilati N, Linley DM, Selvaskandan H, Uchitel O, Hennig MH, Kopp-Scheinpflug C, Forsythe ID. Acoustic trauma slows AMPA receptor-mediated EPSCs in the auditory brainstem, reducing GluA4 subunit expression as a mechanism to rescue binaural function. J Physiol. 2016 Jul 1;594(13):3683-703.
10. Itzcovich T, Xi Z, Martinetto H, Chrem-Méndez P, Russo MJ, de Ambrosi B,.Uchitel OD, Nogués M, Silva E, Rojas G, Bagnatti P, Amengual A, Campos J, Rogaeva E, St George-Hyslop P, Allegri R, Sevlever G, Surace EI. Analysis of C9orf72 in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Argentina. Neurobiol Aging. 2016 Apr;40:192.e13-5.
11. Inchauspe CG, Pilati N, Di Guilmi MN, Urbano FJ, Ferrari MD, van den Maagdenberg AM, Forsythe ID, Uchitel OD. Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. Hear Res.2015; 319:56-68.
12. Di Guilmi MN, Wang T, Inchauspe CG, Forsythe ID, Ferrari MD, van den Maagdenberg AM, Borst JG, Uchitel OD. Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i. J Neurosci. 2014; 34(21):7047-58.
13. Urbano FJ, Lino NG, González-Inchauspe CM, González LE, Colettis N, VattinoLG, Wunsch AM, Wemmie JA, Uchitel OD. Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice. Am J Physiol Cell Physiol. 306(4):C396-406. 2014.
14. Uchitel O.D. “CaV2.1 (P/Q) voltage activated calcium channels and synaptic transmission in genetic and autoimmune diseases” . in Modulation of Presynaptic Calcium Channels edited by Dr. Gary Stephens and Prof. Sumiko Mochida (Springer Science), 9789400763340, 263-288.
15. Weissmann C, Di Guilmi MN, Urbano FJ, Uchitel OD. Acute effects of pregabalin on the function and cellular distribution of Ca(V)2.1 in HEK293t cells. Brain Res Bull. 2013, 90:107-13
16. Gonzalez Inchauspe C, Urbano FJ, Di Guilmi MN, Ferrari MD, van den Maagdenberg.AM, Forsythe I, Uchitel OD. Presynaptic CaV2.1 calcium channels carrying a familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of Held. J Neurophysiol. 2012, 108(11):2967-76.
17. Uchitel OD. Unequal gains of function are a headache for migraine mechanisms. J Physiol. 2012;590(1):1-2
18. Uchitel OD, Inchauspe CG, Urbano FJ, Di Guilmi MN. Ca(V)2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis. J Physiol Paris. 2012 ; 106(1-2):12-22.
19. Gonzalez LE, Kotler ML, Vattino LG, Conti E, Reisin RC, Mulatz KJ, Snutch TP. Uchitel OD. Amyotrophic lateral sclerosis-immunoglobulins selectively interact with neuromuscular junctions expressing P/Q-type calcium channels. J Neurochem.2011; 119(4):826-38.
20. Pagani MR, Gonzalez LE, Uchitel OD. Autoimmunity in amyotrophic lateral sclerosis: past and present. Neurol Res Int. 2011; 497080. Cited 17
21. Giugovaz-Tropper B, González-Inchauspe C, Di Guilmi MN, Urbano FJ, Forsythe ID, Uchitel OD. P/Q-type calcium channel ablation in a mice glycinergic synapse mediated by multiple types of Ca²+ channels alters transmitter release and short term plasticity. Neuroscience. 2011; 192:219-30.
22. Di Guilmi MN, Urbano FJ, Inchauspe CG, Uchitel OD. Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of ca(v)2.1 calcium channels. J Pharmacol Exp Ther. 2011; 336(3):973-82.
23. Uchitel OD, Di Guilmi MN, Urbano FJ, Gonzalez-Inchauspe C. Acute modulation of calcium currents and synaptic transmission by gabapentinoids. Channels (Austin). 2010; 4(6):490-6. Review.
24. Sterenborg JC, Pilati N, Sheridan CJ, Uchitel OD, Forsythe ID, Barnes-Davies M. Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons. Hear Res. 2010; 270(1-2):119-26
25. Perissinotti PP, Uchitel OD. Adenosine drives recycled vesicles to a slow-release pool at the mouse neuromuscular junction. Eur J Neurosci. 2010; 32(6):985-96. Cited 3
26. Bisagno V, Raineri M, Peskin V, Wikinski SI, Uchitel OD, Llinás RR, Urbano FJ. Effects of T-type calcium channel blockers on cocaine-induced hyperlocomotion and thalamocortical GABAergic abnormalities in mice. Psychopharmacology (Berl).2010; 212(2):205-14.
27. Inchauspe CG, Urbano FJ, Di Guilmi MN, Forsythe ID, Ferrari MD, van den Maagdenberg AM, Uchitel OD. Gain of function in FHM-1 Ca(V)2.1 knock-in mice is related to the shape of the action potential. J Neurophysiol. 2010; 104(1):291-9.