Cargo Conicet: Investigador Asistente
Área: Fisiología y Neurociencias
Tema de Trabajo: Mecanismos y circuitos neuronales involucrados en aprendizaje y memoria
Descripción de trabajo: Estudiamos mecanismos cerebrales que subyacen al aprendizaje y formación de memorias adquiridas por experiencia directa o por transmisión social. Usamos ratones como modelo, y para estudiar los circuitos involucrados usamos metodologías que incluyen análisis de conducta, farmacología, optogenética, quimiogenética, registros electrofisiológicos extracelulares en animales comportándose libremente, microscopía, entre otras.

2019. Candela Medina; Verónica de la Fuente*; Susanne tom Dieck; Belquis Nassim-Assir; Tamas Dalmay; Ina Bartnik; Paula Lunardi; Lucas de Oliveira Alvares; Erin M Schuman; Johannes J Letzkus; Arturo Romano*. “Cofilin 1 involvement in fear memory processing”. En revisión en Neurobiology of Learning and Memory. *co-corresponding authors.

2019. de la Fuente V1*, Medina C1, Falasco G, Urrutia L, Kravitz AV, Urbano F, Vazquez S, Pedreira ME, Romano A. The lateral neocortex is critical for contextual fear memory reconsolidation. Sci Rep. 2019 Aug 21;9(1):12157. doi: 10.1038/s41598-019-48340-9. 1: both authors contributed equally. *corresponding author.

2019. Zalcman G, Federman N, Fiszbein A, de la Fuente V, Ameneiro L, Schor I, Romano A. Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice. Mol Neurobiol. 2019 Feb;56(2):1437-1450. doi: 10.1007/s12035-018-1144-3.

2018. Lunardi P, Sachser RM, Sierra RO, Pedraza LK, Medina C, de la Fuente V, Romano A, Quillfeldt JA, de Oliveira Alvares L. Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction. Mol Neurobiol. 2018 Feb;55(2):958-967. doi: 10.1007/s12035-016-0361-x.

2015. Zalcman GP, Federman N, de la Fuente V, Romano A. Nuclear factor kappa B-dependent zif268 expression in hippocampus is required for recognition memory in mice. Neurobiol Learn Mem. 2015 Mar;119:10-7. doi: 10.1016/j.nlm.2014.12.013.

2015. de la Fuente V, Federman N, Zalcman G, Salles A, Freudenthal, R and Romano A. NF-κB transcription factor role in consolidation and reconsolidation of persistent memories. Front Mol Neurosci. 2015 Sep 9;8:50. doi: 10.3389/fnmol.2015.00050. eCollection 2015. Review.

2014. de la Fuente V, Federman N, Fustiñana MS, Zalcman GP, and Romano A. Calcineurin phosphatase as a regulator of fear memory formation: control on NF-κB signaling in consolidation and reconsolidation. Hippocampus. 2014 Dec;24(12):1549-61. doi: 10.1002/hipo.22334.

2014. Federman N, Zalcman G, de la Fuente V, Fustiñana MS, Romano A. Epigenetic mechanisms and memory strength: a comparative study. J Physiol Paris. 2014 Sep-Dec;108(4-6):278-85. doi: 10.1016/j.jphysparis.2014.06.003. Epub 2014 Jun 28. Review.

2014. Fustiñana MS, de la Fuente V, Federman N, Freudenthal R and Romano A. Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory. Learn Mem. 2014 Aug 18;21(9):478-87. doi: 10.1101/lm.035998.114.

2014. Ogara MF, Belluscio LM, de la Fuente V, Berardino BG, Sonzogni SV, Byk L, Marazita M, Cánepa ET. CDK5-mediated phosphorylation of p19ink4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions. Biochim Biophys Acta. 2014 Jul;1843(7):1309-24. doi: 10.1016/j.bbamcr.2014.03.026.

2013. Federman N, de la Fuente V, Zalcman G, Corbi N, Onori A, Passananti C, Romano A. Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory. J Neurosci. 2013 Apr 24;33(17):7603-14. doi: 10.1523/JNEUROSCI.4181-12.2013.

2011. de la Fuente V, Freudenthal R, Romano A. Reconsolidation or extinction: transcription factor switch in the determination of memory course after retrieval. J Neurosci. 2011 Apr 13;31(15):5562-73. doi: 10.1523/JNEUROSCI.6066-10.2011.

2007. Boccia M, Freudenthal R, Blake M, de la Fuente V, Acosta G, Baratti C, Romano A. Activation of hippocampal nuclear factor-kappa B by retrieval is required for memory reconsolidation. J Neurosci. 2007 Dec 5;27(49):13436-45.