Cargo Conicet: Investigador Principal
Área: Biología Molecular y Celular
Tema de Trabajo: Biología de Sistemas Moleculares de Toma de Decisiones
Descripción de trabajo: El grupo estudia los sistemas moleculares que gobiernan la transducción y procesamiento de señales en Saccharomyces cerevisiae y en células de mamífero en cultivo y su efecto sobre la toma de decisiones que afectan el destino celular, utilizando un enfoque de biología de sistemas, combinando modelado matemático con experimentación a nivel de células individuales.

1. Gustavo Vasen, Paula Dunayevich and Alejandro Colman-Lerner. (2020) Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient sensing in Saccharomyces cerevisiae. Proc.Natl.Acad.Sci.U.S.A, epub Mar 9 doi.org/10.1073/pnas.1912505117

2. María Victoria Repetto, Matthew J. Winters, Alan Bush, Wolfgang Reiter, David Maria Hollenstein, Gustav Ammerer, Peter M. Pryciak*, and Alejandro Colman-Lerner*. (2018) CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5. Molecular Cell Vol 69, Issue 6, 15 March 2018, Pages 938–952.e6. doi.org/10.1016/j.molcel.2018.02.018. *: co-corresponding authors.

3. Alan Bush*, Gustavo Vasen*, Andreas Constantinou#, Paula Dunayevich#, Inés Patop, Matías Blaustein, and Alejandro Colman-Lerner. (2016) Yeast GPCR signaling reflects the fraction of occupied receptors, not the number. Molecular Systems Biology 12(12):898. doi.org/10.15252/msb.20166910. * o #: equally contributing authors.

4. Andreas Doncic, Oguzhan Atay, Ervin Valk, Alicia Grande, Alan Bush, Gustavo Vasen, Alejandro Colman-Lerner, Mart Loog, and Jan M. Skotheim. (2015) Compartmentalization of a Bistable Switch Enables Memory to Cross a Feedback-Driven Transition. Cell 160, 1182–1195. doi.org/10.1016/j.cell.2015.02.032

5. Ventura, A. C. Bush, A. Vasen, G. Goldin, M. Burkinshaw, B. Bhattacharjee, Nirveek, Folch, A. Brent, R. Chernomoretz, A and Colman-Lerner, A. (2014) Utilization of extracellular information before equilibrium receptor binding expands and shifts the input dynamic range. Proc.Natl.Acad.Sci.U.S.A, Sep 16;111(37):E3860-9. Epub Aug 29. doi: 10.1073/pnas.1322761111.

6. Yu, R. C., Pesce, C. G., Colman-Lerner, A., Lok, L., Pincus, D., Serra, E., Holl, M., Benjamin, K., Gordon, A. and Brent, R. (2008). Negative feedback that improves information transmission in yeast signalling. Nature 465, 755-761. doi.org/0.1038/nature07513.

7. Colman-Lerner, A.*#, Gordon, A.*#, Serra, E., Chin, T., Resnekov, O., Endy, D., Pesce, C.G., and Brent, R#. (2005). Regulated cell-to-cell variation in a cell-fate decision system. Nature 437, 699-706. *: equally contributing authors. # corresponding authors). doi.org/10.1038/nature03998.

8. Colman-Lerner, A.*, Chin, T.E., and Brent, R. (2001). Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell 107, 739-750. doi.org/10.1016/s0092-8674(01)00596-7. * corresponding author.